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Active Pharmaceutical Ingredients Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2019-2024

The global active pharmaceutical ingredients market was worth US$ 176.3 Billion in 2018. Active pharmaceutical ingredient (API), is the term that is used to refer to the biologically active component of a drug (e.g. tablet, capsule). A drug is usually composed of several components. The API represents the primary ingredient. Other ingredients are commonly known as "excipients. Sometimes a drug can contain several APIs and its effect on a patient depends on the dosage prescribed and can vary from person to person. In combination therapies, two or more than two active ingredients are used to treat different symptoms in different ways. Stringent quality control is a mandate when it comes to the manufacturing of drugs as the API represents the main component considered while making the prescription.

Active Pharmaceutical Ingredients Market Report

Pharmaceutical manufacturing occurs in two general steps. In the first step, manufacturers convert raw materials into APIs. The second step involves creating the final formulation by mixing APIs and excipients into tablets, capsules, solutions, etc.  and finally packaging the drug for the end users. Manufacturers either sell APIs in the open market (also known as the merchant market) or use them as inputs to make their final formulations. The global API market is extremely competitive with a number of large and small manufacturers. Firms that engage in API manufacturing generally specialize and target their manufacturing based on a combination of the firms in-house skills and market opportunities. Catalyzed by lower costs, API manufacturing has gradually been shifting from the historical leaders in Western countries to manufacturers based in India and China.

Active Pharmaceutical Ingredients Market By Region

The global demand of APIs is currently exhibiting strong growth. One of the major drivers of this market is the rising number of blockbuster patent expiries creating a significant opportunity for generic APIs. Moreover, there has been a strong demand for APIs for biologicals. The global market for biologicals is currently exhibiting strong growth catalyzed by their high potency and ability to treat diseases beyond the scope of small molecule drugs. This is creating a strong demand for APIs for branded biological drugs and their biosimilar versions. Other factors catalyzing the global demand of APIs include ageing population, rising expenditures on healthcare, increasing prevalence of lifestyle diseases, etc. Looking forward, the market value is projected to reach US$ 247.2 Billion by 2024, exhibiting a CAGR of 5.8% during 2019-2024.

Market Summary:

  • Based on the drug type, the market has been segmented as innovative active pharmaceutical ingredients and generic active pharmaceutical ingredients.
  • Based on the type of manufacturer, the market has been segmented as captive manufacturers and merchant API manufacturers.
  • Based on the type of synthesis, the market has been segmented as synthetic active pharmaceutical ingredients and biotech active pharmaceutical ingredients.
  • Based on the therapeutic application, the market has been segmented as oncology, cardiovascular disease, diabetes, central nervous system and neurological disorders, endocrinology and others.
  • Region-wise, the market has been segmented into North America, Europe, Asia Pacific, Middle East and Africa, and Latin America.
  • The competitive landscape of the market has also been examined with some of the key players being Pfizer, Inc., Novartis International AG, Sanofi, Boehringer Ingelheim, Bristol-Myers Squibb, Teva Pharmaceutical Industries Ltd., ELI Lilly and Company, GlaxoSmithKline, Merck & Co., Inc. and Abbvie Inc.
     

Key Questions Answered in This Report:

  • How has the global active pharmaceutical ingredients market performed so far and how will it perform in the coming years?
  • What are the key regional markets in the global active pharmaceutical ingredients industry?
  • What is the breakup of the global active pharmaceutical ingredients market on the basis of drug type?
  • What is the breakup of the global active pharmaceutical ingredients market on the basis of type of manufacturer?
  • What is the breakup of the global active pharmaceutical ingredients market on the basis of synthesis?
  • What is the breakup of the global active pharmaceutical ingredients market on the basis of therapeutic application?
  • What are the various stages in the value chain of the global active pharmaceutical ingredients market?
  • What are the key driving factors and challenges in the global active pharmaceutical ingredients market?
  • What is the structure of the global active pharmaceutical ingredients market and who are the key players?
  • What is the degree of competition in the global active pharmaceutical ingredients market?
  • How are active pharmaceutical ingredients manufactured?

1   Preface
2   Scope and Methodology

    2.1    Objectives of the Study
    2.2    Stakeholders
    2.3    Data Sources
        2.3.1    Primary Sources
        2.3.2    Secondary Sources
    2.4    Market Estimation
        2.4.1    Bottom-Up Approach
        2.4.2    Top-Down Approach
    2.5    Forecasting Methodology
3   Executive Summary
4   Introduction

    4.1    Overview
    4.2    Key Industry Trends
5   Global Active Pharmaceutical Ingredients Market 
    5.1    Market Overview
    5.2    Market Performance
    5.3    Market Breakup by Drug Type
    5.4    Market Breakup by Type of Manufacturer
    5.5    Market Breakup by Type of Synthesis 
    5.6    Market Breakup by Therapeutic Application
    5.7    Market Breakup by Region
    5.8    Market Forecast
    5.9    SWOT Analysis
        5.9.1    Overview
        5.9.2    Strengths
        5.9.3    Weaknesses
        5.9.4    Opportunities
        5.9.5    Threats
    5.10    Value Chain Analysis
    5.11    Porters Five Forces Analysis
        5.11.1    Overview
        5.11.2    Bargaining Power of Buyers
        5.11.3    Bargaining Power of Suppliers
        5.11.4    Degree of Competition
        5.11.5    Threat of New Entrants
        5.11.6    Threat of Substitutes
    5.12    Price Analysis
        5.12.1    Price Indicators
        5.12.2    Price Structure
        5.12.3    Margin Analysis
6   Market Breakup by Drug Type
    6.1    Innovative Active Pharmaceutical Ingredients 
    6.2    Generic Active Pharmaceutical Ingredients
7   Market Breakup by Type of Manufacturer
    7.1    Captive Manufacturers 
    7.2    Merchant API Manufacturers 
         7.2.1   Innovative Merchant API Manufacturers
         7.2.2   Generic Merchant API Manufacturers
8   Market Breakup by Type of Synthesis 
    8.1    Synthetic Active Pharmaceutical Ingredients
        8.1.1      Market Breakup by Type
             8.1.1.1  Innovative Synthetic APIs
             8.1.1.2  Generic Synthetic APIs
    8.2    Biotech Active Pharmaceutical Ingredients
       8.2.1      Market Breakup by Type
              8.2.1.1  Innovative Biotech APIs
              8.2.1.2  Biosimilars
       8.2.2      Market Breakup By Product 
              8.2.2.1  Monoclonal Antibodies 
              8.2.2.2  Vaccines 
              8.2.2.3  Cytokines 
              8.2.2.4  Fusion Proteins 
              8.2.2.5  Therapeutic Enzymes 
              8.2.2.6  Blood Factors 
       8.2.3     Market Breakup By Expression System 
              8.2.3.1  Mammalian Expression Systems 
              8.2.3.2  Microbial Expression Systems 
              8.2.3.3  Yeast Expression Systems 
              8.2.3.4  Plant Expression Systems 
              8.2.3.5  Insect Expression Systems 
9   Market Breakup by Therapeutic Application
    9.1    Oncology 
    9.2    Cardiovascular Disease 
    9.3    Diabetes 
    9.4    Central Nervous System and Neurological Disorders 
    9.5    Endocrinology 
    9.6    Others 
10  Market Breakup by Region
    10.1    North America 
    10.2    Europe
    10.3    Asia Pacific
    10.4    Middle East and Africa
    10.5    Latin America
11  Manufacturing Process
    11.1    Product Overview
    11.2    Raw Material Requirements
    11.3    Manufacturing Process
    11.4    Key Success and Risk Factors
12  Competitive Landscape
    12.1    Market Structure
    12.2    Key Players
    12.3    Profiles of Key Players
        12.3.1    Pfizer, Inc. 
        12.3.2    Novartis International AG 
        12.3.3    Sanofi 
        12.3.4    Boehringer Ingelheim 
        12.3.5    Bristol-Myers Squibb 
        12.3.6    Teva Pharmaceutical Industries Ltd.  
        12.3.7    ELI Lilly and Company 
        12.3.8    GlaxoSmithKline 
        12.3.9    Merck & Co., Inc. 
        12.3.10    Abbvie Inc. 


List of Figures

Figure 1: Global: Active Pharmaceutical Ingredients Market: Major Drivers and Challenges
Figure 2: Global: Active Pharmaceutical Ingredients Market: Sales Value (in Billion US$), 2013-2018
Figure 3: Global: Active Pharmaceutical Ingredients Market: Breakup by Drug Type (in %), 2018
Figure 4: Global: Active Pharmaceutical Ingredients Market: Breakup by Type of Manufacturer (in %), 2018
Figure 5: Global: Active Pharmaceutical Ingredients Market: Breakup by Type of Synthesis (in %), 2018
Figure 6: Global: Active Pharmaceutical Ingredients Market: Breakup by Therapeutic Application (in %), 2018
Figure 7: Global: Active Pharmaceutical Ingredients Market: Breakup by Region (in %), 2018
Figure 8: Global: Active Pharmaceutical Ingredients Market Forecast: Sales Value (in Billion US$), 2019-2024
Figure 9: Global: Active Pharmaceutical Ingredients Industry: SWOT Analysis
Figure 10: Global: Active Pharmaceutical Ingredients Industry: Value Chain Analysis
Figure 11: Global: Active Pharmaceutical Ingredients Industry: Porter’s Five Forces Analysis
Figure 12: Global: Active Pharmaceutical Ingredients (Innovative Active Pharmaceutical Ingredients) Market: Sales Value (in Million US$), 2013 & 2018
Figure 13: Global: Active Pharmaceutical Ingredients (Innovative Active Pharmaceutical Ingredients) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 14: Global: Active Pharmaceutical Ingredients (Generic Active Pharmaceutical Ingredients) Market: Sales Value (in Million US$), 2013 & 2018
Figure 15: Global: Active Pharmaceutical Ingredients (Generic Active Pharmaceutical Ingredients) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 16: Global: Active Pharmaceutical Ingredients (Captive Manufacturers) Market: Sales Value (in Million US$), 2013 & 2018
Figure 17: Global: Active Pharmaceutical Ingredients (Captive Manufacturers) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 18: Global: Merchant API Manufacturers Market: Sales Value (in Billion US$), 2013-2018
Figure 19: Global: Merchant API Manufacturers Market: Breakup by Type (in %), 2018
Figure 20: Global: Merchant API Manufacturers (Innovative Merchant API Manufacturers) Market: Sales Value (in Million US$), 2013 & 2018
Figure 21: Global: Merchant API Manufacturers (Innovative Merchant API Manufacturers) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 22: Global: Merchant API Manufacturers (Generic Merchant API Manufacturers) Market: Sales Value (in Million US$), 2013 & 2018
Figure 23: Global: Merchant API Manufacturers (Generic Merchant API Manufacturers) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 24: Global: Merchant API Manufacturers Market: Breakup by by Synthesis (in %), 2018
Figure 25: Global: Merchant API Manufacturers (Synthetic APIs) Market: Sales Value (in Million US$), 2013 & 2018
Figure 26: Global: Merchant API Manufacturers (Synthetic APIs) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 27: Global: Merchant API Manufacturers (Biotech APIs) Market: Sales Value (in Million US$), 2013 & 2018
Figure 28: Global: Merchant API Manufacturers (Biotech APIs) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 29: Global: Merchant API Manufacturers Market Forecast: Sales Value (in Billion US$), 2019-2024
Figure 30: Global: Synthetic Active Pharmaceutical Ingredients Market: Sales Value (in Billion US$), 2013-2018
Figure 31: Global: Synthetic Active Pharmaceutical Ingredients Market: Breakup by Type (in %), 2018
Figure 32: Global: Synthetic Active Pharmaceutical Ingredients (Innovative Synthetic APIs) Market: Sales Value (in Million US$), 2013 & 2018
Figure 33: Global: Synthetic Active Pharmaceutical Ingredients (Innovative Synthetic APIs) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 34: Global: Synthetic Active Pharmaceutical Ingredients (Generic Synthetic APIs) Market: Sales Value (in Million US$), 2013 & 2018
Figure 35: Global: Synthetic Active Pharmaceutical Ingredients (Generic Synthetic APIs) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 36: Global: Synthetic Active Pharmaceutical Ingredients Market Forecast: Sales Value (in Billion US$), 2019-2024
Figure 37: Global: Biotech Active Pharmaceutical Ingredients Market: Sales Value (in Billion US$), 2013-2018
Figure 38: Global: Biotech Active Pharmaceutical Ingredients Market: Breakup by Type (in %), 2018
Figure 39: Global: Biotech Active Pharmaceutical Ingredients (Innovative Biotech APIs) Market: Sales Value (in Million US$), 2013 & 2018
Figure 40: Global: Biotech Active Pharmaceutical Ingredients (Innovative Biotech APIs) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 41: Global: Biotech Active Pharmaceutical Ingredients (Biosimilars) Market: Sales Value (in Million US$), 2013 & 2018
Figure 42: Global: Biotech Active Pharmaceutical Ingredients (Biosimilars) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 43: Global: Biotech Active Pharmaceutical Ingredients Market: Breakup by Product (in %), 2018
Figure 44: Global: Biotech Active Pharmaceutical Ingredients (Monoclonal Antibodies) Market: Sales Value (in Million US$), 2013 & 2018
Figure 45: Global: Biotech Active Pharmaceutical Ingredients (Monoclonal Antibodies) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 46: Global: Biotech Active Pharmaceutical Ingredients (Vaccines) Market: Sales Value (in Million US$), 2013 & 2018
Figure 47: Global: Biotech Active Pharmaceutical Ingredients (Vaccines) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 48: Global: Biotech Active Pharmaceutical Ingredients (Cytokines) Market: Sales Value (in Million US$), 2013 & 2018
Figure 49: Global: Biotech Active Pharmaceutical Ingredients (Cytokines) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 50: Global: Biotech Active Pharmaceutical Ingredients (Fusion Proteins) Market: Sales Value (in Million US$), 2013 & 2018
Figure 51: Global: Biotech Active Pharmaceutical Ingredients (Fusion Proteins) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 52: Global: Biotech Active Pharmaceutical Ingredients (Therapeutic Enzymes) Market: Sales Value (in Million US$), 2013 & 2018
Figure 53: Global: Biotech Active Pharmaceutical Ingredients (Therapeutic Enzymes) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 54: Global: Biotech Active Pharmaceutical Ingredients (Blood Factors) Market: Sales Value (in Million US$), 2013 & 2018
Figure 55: Global: Biotech Active Pharmaceutical Ingredients (Blood Factors) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 56: Global: Biotech Active Pharmaceutical Ingredients Market: Breakup by Expression System (in %), 2018
Figure 57: Global: Biotech Active Pharmaceutical Ingredients (Mammalian Expression Systems) Market: Sales Value (in Million US$), 2013 & 2018
Figure 58: Global: Biotech Active Pharmaceutical Ingredients (Mammalian Expression Systems) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 59: Global: Biotech Active Pharmaceutical Ingredients (Microbial Expression Systems) Market: Sales Value (in Million US$), 2013 & 2018
Figure 60: Global: Biotech Active Pharmaceutical Ingredients (Microbial Expression Systems) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 61: Global: Biotech Active Pharmaceutical Ingredients (Yeast Expression Systems) Market: Sales Value (in Million US$), 2013 & 2018
Figure 62: Global: Biotech Active Pharmaceutical Ingredients (Yeast Expression Systems) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 63: Global: Biotech Active Pharmaceutical Ingredients (Plant Expression Systems) Market: Sales Value (in Million US$), 2013 & 2018
Figure 64: Global: Biotech Active Pharmaceutical Ingredients (Plant Expression Systems) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 65: Global: Biotech Active Pharmaceutical Ingredients (Insect Expression Systems) Market: Sales Value (in Million US$), 2013 & 2018
Figure 66: Global: Biotech Active Pharmaceutical Ingredients (Insect Expression Systems) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 67: Global: Biotech Active Pharmaceutical Ingredients Market Forecast: Sales Value (in Billion US$), 2019-2024
Figure 68: Global: Active Pharmaceutical Ingredients (Oncology) Market: Sales Value (in Million US$), 2013 & 2018
Figure 69: Global: Active Pharmaceutical Ingredients (Oncology) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 70: Global: Active Pharmaceutical Ingredients (Cardiovascular Disease) Market: Sales Value (in Million US$), 2013 & 2018
Figure 71: Global: Active Pharmaceutical Ingredients (Cardiovascular Disease) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 72: Global: Active Pharmaceutical Ingredients (Diabetes) Market: Sales Value (in Million US$), 2013 & 2018
Figure 73: Global: Active Pharmaceutical Ingredients (Diabetes) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 74: Global: Active Pharmaceutical Ingredients (Central Nervous System and Neurological Disorders) Market: Sales Value (in Million US$), 2013 & 2018
Figure 75: Global: Active Pharmaceutical Ingredients (Central Nervous System and Neurological Disorders) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 76: Global: Active Pharmaceutical Ingredients (Endocrinology) Market: Sales Value (in Million US$), 2013 & 2018
Figure 77: Global: Active Pharmaceutical Ingredients (Endocrinology) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 78: Global: Active Pharmaceutical Ingredients (Other Applications) Market: Sales Value (in Million US$), 2013 & 2018
Figure 79: Global: Active Pharmaceutical Ingredients (Other Applications) Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 80: North America: Active Pharmaceutical Ingredients Market: Sales Value (in Million US$), 2013 & 2018
Figure 81: North America: Active Pharmaceutical Ingredients Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 82: Europe: Active Pharmaceutical Ingredients Market: Sales Value (in Million US$), 2013 & 2018
Figure 83: Europe: Active Pharmaceutical Ingredients Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 84: Asia Pacific: Active Pharmaceutical Ingredients Market: Sales Value (in Million US$), 2013 & 2018
Figure 85: Asia Pacific: Active Pharmaceutical Ingredients Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 86: Middle East and Africa: Active Pharmaceutical Ingredients Market: Sales Value (in Million US$), 2013 & 2018
Figure 87: Middle East and Africa: Active Pharmaceutical Ingredients Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 88: Latin America: Active Pharmaceutical Ingredients Market: Sales Value (in Million US$), 2013 & 2018
Figure 89: Latin America: Active Pharmaceutical Ingredients Market Forecast: Sales Value (in Million US$), 2019-2024
Figure 90: Active Pharmaceutical Ingredients Manufacturing: Process Flow


List of Tables

Table 1: Global: Active Pharmaceutical Ingredients Market: Key Industry Highlights, 2018 and 2024
Table 2: Global: Active Pharmaceutical Ingredients Market Forecast: Breakup by Drug (in Million US$), 2019-2024
Table 3: Global: Active Pharmaceutical Ingredients Market Forecast: Breakup by Type of Manufacturer (in Million US$), 2019-2024
Table 4: Global: Active Pharmaceutical Ingredients Market Forecast: Breakup by Type of Synthesis (in Million US$), 2019-2024
Table 5: Global: Active Pharmaceutical Ingredients Market Forecast: Breakup by Therapeutic Application (in Million US$), 2019-2024
Table 6: Global: Active Pharmaceutical Ingredients Market Forecast: Breakup by Region (in Million US$), 2019-2024
Table 7: Active Pharmaceutical Ingredients: Raw Material Requirements
Table 8: Global: Active Pharmaceutical Ingredients Market Structure
Table 9: Global: Active Pharmaceutical Ingredients Market: Key Players

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