Japan Oligonucleotide Synthesis Market Expected to Reach USD 603.0 Million by 2033 - IMARC Group

Japan Oligonucleotide Synthesis Market Statistics, Outlook, and Regional Analysis 2025-2033

The Japan oligonucleotide synthesis market size was valued at USD 204.9 Million in 2024, and it is expected to reach USD 603.0 Million by 2033, exhibiting a growth rate (CAGR) of 11.42% from 2025 to 2033.

The market for oligonucleotide synthesis in Japan is growing significantly due to developments in synthetic biology and biotechnology. Also, the use of oligonucleotide-based therapies to treat chronic illnesses and genetic disorders has prompted the demand for high-quality synthesis and manufacturing capabilities. The emphasis is also pushing the market's limitations on precision medicine and the growing demand for scalable and economical manufacturing techniques. In July 2024, WXi TIDES expanded its CRDMO platform, offering seamless services from discovery to commercial manufacturing of oligonucleotide therapeutics. This included capabilities for synthesis scaling, formulation development, and CMC dossier preparation, enabling faster market entry for pharmaceutical companies.

At the same time, a review published in Heliyon in March 2024 emphasized improvements in automated high-throughput DNA synthesis and assembly. These developments prioritize increased precision, lower prices, and scalable production to fulfill the expanding demands of oligonucleotide and synthetic biology applications. In a market like Japan, where precision and advanced technology are essential to preserving competitiveness in the biopharma industry, these advancements are essential for industry growth. Notably, the emphasis on good manufacturing practices to provide by-product safety and compliance with regulatory standards is creating unique opportunities for Japanese firms to cater to both domestic and international markets. Reflecting these trends, Eurofins Genomics inaugurated a state-of-the-art GMP-certified oligonucleotide manufacturing facility in September 2024, enhancing production capacity while segregating RUO and GMP streams. This strategic development highlights the industry's adherence to completing the stringent regulatory requirements for clinical and commercial applications.

Japan Oligonucleotide Synthesis Market Statistics, By Region

The market research report has also provided a comprehensive analysis of all the major regional markets, which include the Kanto region, Kansai/Kinki region, Central/ Chubu region, Kyushu-Okinawa region, Tohoku region, Chugoku region, Hokkaido region, and Shikoku region. The inflating occurrence of genetic disorders and the increasing number of research institutions are augmenting the market.

Kanto Region Oligonucleotide Synthesis Market Trends:

Japan's oligonucleotide research and development is concentrated in Kanto, further driving the region's growth. Biotech companies in Tokyo work together with academic institutions to develop novel treatments and interference medications that focus on oncogenes. Businesses in the area are also incorporating cutting-edge sequencing technologies to expedite oligonucleotide design procedures. The development of nucleic acid-based therapies by regional companies for customized treatments is one significant project that supports the Kanto region as a hub for biotechnology.

Kansai/Kinki Region Oligonucleotide Synthesis Market Trends:

Diagnostic developments in the oligonucleotide industry are highlighted in the Kansai/Kinki region. Additionally, research facilities in Osaka concentrate on enhancing early disease detection mechanisms, like oligonucleotide probes, for quick virus identification. Further biotech clusters researching therapeutic uses, including RNA-based vaccines, are situated in Kyoto. Overall, collaborative studies in Kansai seek to include oligonucleotides in point-of-care diagnostics to increase access to cutting-edge medical treatments.

Central/Chubu Region Oligonucleotide Synthesis Market Trends:

The technology for producing oligonucleotides is advanced in the Chubu region, particularly in Nagoya. Companies in Aichi Prefecture have innovated cost-effective synthesizers that increase production efficiency. The region also invests in automated synthesis systems, reducing errors in large-scale manufacturing. With its industrial expertise, Central/Chubu supports Japan's growing oligonucleotide demand for research and therapeutics, becoming a critical node in the nation’s biotechnology infrastructure.

Kyushu-Okinawa Region Oligonucleotide Synthesis Market Trends:

Fukuoka is evolving oligonucleotide-based computational tools in the Kyushu-Okinawa region to speed up the development of new treatments. Okinawa’s diverse environment inspires research into sequences with potential applications for neglected tropical diseases. The goal of joint initiatives between biotech companies and Fukuoka's tech sector is to increase the efficiency of oligonucleotide design. Besides this, the development of novel treatments is administered by this collaboration, which establishes Kyushu-Okinawa as a pioneer in the region for combining bioinformatics and life sciences.

Tohoku Region Oligonucleotide Synthesis Market Trends:

Tohoku utilizes oligonucleotides to enhance regenerative medicine, stimulating the region's growth. Tohoku University researchers have developed scaffolds incorporating oligonucleotides to facilitate neuron regeneration following trauma. Moreover, the region's emphasis on healthcare innovation during disaster recovery is driving its demand. Also, the country's adherence to managing health issues with innovative solutions is seen in the local biotech industry's vigorous ramping up of manufacturing for clinical trials.

Chugoku Region Oligonucleotide Synthesis Market Trends:

The Chugoku region is primarily concerned with oligonucleotide applications in the agriculture industry. In this region, researchers are creating oligonucleotide-based approaches to combat crop diseases, thereby improving productivity and sustainability. Concurrent with this, these programs demonstrate how Chugoku successfully manages concerns of food security by fusing biotechnology and agriculture.

Hokkaido Region Oligonucleotide Synthesis Market Trends:

Hokkaido prioritizes research into oligonucleotide stability under extreme conditions. Sapporo-based institutions study modifications to extend the shelf life of oligonucleotide products, ensuring efficacy during transport. These advancements are particularly vital for distribution networks. Hokkaido’s research in stability and environmental resilience contributes to the production of reliable nucleic acid-based products, supporting applications in both diagnostics and therapeutics.

Shikoku Region Oligonucleotide Synthesis Market Trends:

Shikoku, led by Ehime Prefecture, focuses on producing essential reagents for oligonucleotide synthesis. In addition, regional producers supply high-purity phosphoramidites to fulfill rising demand both domestically and abroad. Furthermore, these chemicals are necessary for precisely manufacturing therapeutic oligonucleotides. Also, the region's ability to maintain large-scale oligonucleotide manufacture is supported by Shikoku's expertise in chemical production.

Top Companies Leading in the Japan Oligonucleotide Synthesis Industry

This report provides detailed research on the industry dynamics in the oligonucleotide synthesis market of Japan. Besides, it contains elaborated profiles of prominent industry participants, underscoring their business strategies, recent developments, and market subsidies. Stakeholders can comprehend the key elements propelling growth and innovation in the industry driven by a thorough review, which offers insightful details on the competitive landscape impacting the market. Eurofins Genomics inaugurated a state-of-the-art GMP-certified oligonucleotide manufacturing facility in September 2024, enhancing production capacity while segregating RUO and GMP streams.

Japan Oligonucleotide Synthesis Market Segmentation Coverage

• On the basis of the product, the market has been bifurcated into synthesized oligonucleotide products, reagents, equipment, and services. Synthesized products push innovation with their versatility in research and therapeutic applications. Conversely, reagents, equipment, and services support seamless experimental workflows.
• Based on the application, the market is categorized into PCR primers, PCR assays and panels, sequencing, DNA microarrays, fluorescence in-situ hybridization (FISH), antisense oligonucleotides, and others. These oligonucleotides are vital tools in molecular biology, enabling precise detection, analysis, and manipulation of genetic material for diverse applications.
• On the basis of the end use, the market has been divided into pharmaceutical and biotechnology companies, hospital and diagnostic laboratories, and academic research institutes. They drive innovation in healthcare and research by developing therapies, expanding diagnostic techniques, and adding to the understanding of biological processes and disease mechanisms.

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