Orthobiologics Market

Orthobiologics Market Size:

The global orthobiologics market size reached USD 6.3 Billion in 2024. Looking forward, IMARC Group expects the market to reach USD 9.4 Billion by 2033, exhibiting a growth rate (CAGR) of 4.31% during 2025-2033. North America currently represents the largest region owing to the high prevalence of musculoskeletal disorders, expanding geriatric population, and widespread trends of engaging in high levels of physical activity and sports. The rising demand for minimally invasive surgeries (MIS), ongoing advancements in biologic treatments, and ongoing technological innovations in bone grafts, stem cell therapy, and regenerative medicine are some of the key factors contributing to the market expansion.

Market Size & Forecasts:

• Orthobiologics market was valued at USD 6.3 Billion in 2024.
• The market is projected to reach USD 9.4 Billion by 2033, at a CAGR of 4.31 % from 2025-2033.

Dominant Segments:

• Product: Viscosupplementation products account for the majority of the market share owing to their effectiveness in treating osteoarthritis, particularly of the knee.
• Type: Knee holds the largest share due to the high incidence of degenerative conditions in knees like osteoarthritis and injuries such as ligament tears and cartilage damage. 
• Application: Osteoarthritis and degenerative arthritis represent the leading market segment due to their widespread prevalence and impact. 
• End User: Hospitals and ambulatory centers exhibit a clear dominance in the market due to their comprehensive diagnostic and treatment capabilities.
• Region: North America leads the market with its high prevalence of musculoskeletal disorders, such as osteoarthritis, expanding geriatric population, and widespread trends of engaging in high levels of physical activity and sports. 

 Key Players:

• The leading companies in the market include Arthrex Inc, Globus Medical Inc., Integra LifeSciences, Johnson & Johnson, Medline Industries Inc., Medtronic plc, NuVasive Inc, Orthofix Medical Inc., Smith & Nephew plc, Stryker Corporation, Terumo Corporation, Wright Medical Group N.V., Zimmer Biomet, etc.

Key Drivers of Market Growth:

• Aging Population: Global growth in the aging population is driving the demand for orthobiologics, with the older population at higher risk of suffering from musculoskeletal ailments like osteoarthritis and joint degeneration that are in need of sophisticated treatment.
• Advancements in Medical Technology: Growth in medical technologies such as stem cell therapy, platelet-rich plasma (PRP), and tissue-engineering methods is enhancing the efficacy and safety of treatments, hence broadening their clinical uses.
• Minimally Invasive Therapies: Growing demand for minimally invasive therapies, with their faster recovery rates and reduced complications as compared to conventional surgical approaches, is driving the use of orthobiologic treatments for regeneration and repair of joints.
• Growing Sports Injuries and Active Lifestyles: Increasing involvement in sports and exercise, combined with the rising focus on fitness, is causing a rise in sports-related injuries, further catalyzing the need for successful regenerative therapies.
• Reimbursement Policies and Regulatory Support: Greater insurance coverage and supportive regulatory environments are helping to deliver patients to orthobiologic therapies, stimulating market growth.

Future Outlook:

• Strong Growth Outlook: The market for orthobiologics is expected to grow steadily, driven by continuous technological innovation, rising awareness of non-surgical treatments, and the expanding number of people opting for alternatives to conventional surgery.
• Market Evolution: The market is likely to see a movement from niche, expensive treatments towards more affordable, mainstream options for different musculoskeletal disorders, thus establishing orthobiologics as an orthopedic mainstream option.

The market for orthobiologics is undergoing changes as different trends continue to influence the landscape of musculoskeletal therapies. Awareness about musculoskeletal well-being and the advantages of treatment with orthobiologics is on a rise, fueled by healthcare initiatives, educational campaigns, and the expanding access to information online. As people learn more about the ability of biologic therapies to treat chronic pain, joint degeneration, and soft tissue trauma, the need for such treatments grows. Doctors are also learning more about the most current advances in orthobiologics so that they can better inform patients about the options available to them. Growing exposure to orthobiologic therapies among professional and amateur athletes is driving popularity, as renowned athletes and teams increasingly seek out biologic treatments for rehabilitation. As knowledge spreads, greater numbers of patients are scheduling consultations regarding biologic therapies, driving demand for orthobiologics in a wide range of patients.

Orthobiologics Market Trends:

Growing Demand for Non-Surgical Treatments

The market for orthobiologics is witnessing tremendous growth because of the escalating demand for non-invasive treatment. More patients are now turning towards minimally invasive (MI) procedures that induce quicker recovery and reduced risk of complications. Orthobiologics like platelet-rich plasma (PRP) and stem cell therapies are offering successful alternatives to conventional surgeries for musculoskeletal injuries, osteoarthritis, and joint degeneration. With more patients looking for alternatives to prolonged hospitalization and rehabilitation, physicians are increasingly using orthobiologic treatment to satisfy these demands. Increased awareness of the advantages of biologic therapy, as well as a growing body of clinical evidence that favors them as an effective method for tissue repair and regeneration, are driving the use of non-invasive treatments. This trend will likely continue to propel the market's growth because patients and healthcare systems alike are increasingly looking for less invasive, more cost-efficient, and more effective modes of treatment. IMARC Group predicts that the global minimally invasive surgery market is projected to attain USD 94.9 Billion by 2033.

Advances in Regenerative Medicine

The orthobiologics industry is being driven by continued developments in regenerative medicine. Advances in technology and research are continuously enhancing the efficacy of treatments such as stem cell therapy, hyaluronic acid injections, and PRP. The developments are allowing orthobiologic therapies to regenerate or restore damaged tissues, expedite recovery, and decrease the demand for extensive surgical procedures. In addition, advances in tissue engineering and formulating biologic products are improving the efficacy and safety of such treatments and providing opportunities for the management of musculoskeletal diseases. With continued progress in regenerative medicine, orthobiologic treatments are becoming more sophisticated and well-liked and are gaining popularity among healthcare providers as well as patients. The progressive advancements in the regenerative medicine space are by far driving the clinical uses of orthobiologics wider, providing novel therapies for injuries like tendon damage and cartilage injury, as well as for chronic joint pain. In 2025, The University of Bridgeport (UB) introduced an innovative certificate program in the fast-developing area of Regenerative Medicine, in partnership with the prestigious TulsiHub Institute. This 12-week, CE-approved program aims to prepare healthcare professionals and students with top-tier skills in regenerative therapies, allowing graduates to obtain seed funding to start their own clinics upon finishing. Funding access enables healthcare providers to deliver these advanced methods straight to patients in their local areas. Weekend classes for the initial three courses like Comprehensive Regenerative Dermatology and Orthopedic Infusion Care, Regenerative Dermatology and Aesthetics, and Regenerative Orthopedic and Integrative Joint Care started from June.

Growing Sports and Fitness Trends

The increasing popularity of sports and exercise activities is contributing significantly to the growth of the market. As people participate in physical exercise, sports-related injuries like sprain, tears, and fractures are on the rise. Sports persons and physically active individuals are increasingly opting for orthobiologic therapies in order to speed up recovery, mitigate pain, and enhance functionality. These treatments, including PRP injections and stem cell therapies, are now being utilized to address soft tissue injury, cartilage damage, and joint disease. The demand for faster recovery and enhanced performance is driving the use of orthobiologic solutions by both professional athletes and the recreational fitness enthusiast alike. With sports and fitness remaining central to a healthy lifestyle world-wide, the market for orthobiologics is riding this wave by providing cutting-edge, efficient treatment for musculoskeletal injuries, fueling its expansion and wider integration into the healthcare market. As per an article published by Healio in 2024, Orthopedic-related sports injuries in patients aged at least 65 years were projected to increase by 123% by 2040 and may outpace the number of orthopedic surgeons.

Orthobiologics Market Growth Drivers:

Increased Emphasis on Individualized Medicine

The orthobiologics market is experiencing rapid growth as a result of growing emphasis on personalized medicine. Improved genetic research and diagnostic methods are allowing medical practitioners to customize treatments to the individual patient's unique needs. For musculoskeletal conditions, customized orthobiologic therapies are being created to maximize healing based on variables like a patient's genetic makeup, type of injury, and overall health status. By personalizing biologic therapies, including stem cell therapy and PRP injections, to the patient, these treatments are becoming increasingly more effective in stimulating tissue regeneration and enhancing patient outcomes. This movement towards individualized medicine is also being aided by advances in biomarker discovery and the development of targeted therapeutic approaches, further increasing the accuracy and effectiveness of orthobiologic therapies.

Expanding Reimbursement Coverage and Regulatory Approvals

The market for orthobiologics is being driven considerably by growing reimbursement coverage and more positive regulatory approvals. Increasing numbers of countries are now covering biologic therapies in insurance plans, which is enhancing patient access to advanced therapies. Health systems are also increasingly acknowledging the cost-effectiveness of orthobiologic treatments in the long term because of their ability to minimize the necessity for costly surgeries and lengthy rehabilitation. Regulatory authorities, like the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA), are approving new orthobiologic products, which is further increasing confidence in the market. As healthcare reimbursement policies become more inclusive and supportive of regenerative therapies, increasing numbers of patients are becoming able to access these treatments, which is causing wider adoption. This increased reimbursement coverage and regulatory endorsement are making orthobiologics more financially sustainable for healthcare providers and patients alike, thus promoting the expansion of the market.

Rising Awareness of Musculoskeletal and Joint Health

The growing awareness of joint and musculoskeletal health is driving the demand for orthobiologics. As more individuals recognize the importance of maintaining joint health throughout their lives, there is a rising interest in treatments that promote tissue repair, reduce pain, and improve mobility. Public education campaigns and educational programs are gradually raising awareness of musculoskeletal disorders, including arthritis and tendon damage, and the promise of orthobiologic therapies. This increased awareness is compelling patients to seek alternatives to conventional surgical intervention, resulting in a growing use of biologic treatments like PRP injections and stem cell therapy. In addition, as the world population grows older, the need for efficient and less invasive treatments to treat chronic joint conditions keeps on increasing. Consequently, the increased concentration on joint health is fueling market growth.

Orthobiologics Market Segmentation:

IMARC Group provides an analysis of the key trends in each segment of the global orthobiologics market report, along with forecasts at the global, regional and country levels from 2025-2033. Our report has categorized the market based on product, type, application and end user.

Breakup by Product:

• Demineralized Bone Matrix
• Allograft
• Bone Morphogenetic Protein
• Viscosupplementation Products
• Synthetic Bone Substitutes
• Others

Viscosupplementation products account for the majority of the market share

The report has provided a detailed breakup and analysis of the market based on the product. This includes demineralized bone matrix, allograft, bone morphogenetic protein, viscosupplementation products, synthetic bone substitutes, and others. According to the report, viscosupplementation products represented the largest segment.

On the basis of the orthobiologics market research report, viscosupplementation products dominate the market owing to their effectiveness in treating osteoarthritis, particularly of the knee. These substances, which are mostly made of hyaluronic acid, are injected into joints to cushion and lubricate them, thereby minimizing discomfort and enhancing range of motion. As osteoarthritis is highly prevalent, especially in the aging population, the demand for non-surgical and minimally invasive treatment options like viscosupplementation is high. Moreover, viscosupplements offer relief without the significant risks or recovery time associated with joint replacement surgery. Therefore, the ease of administration, growing preference for non-invasive treatments, and increasing awareness of viscosupplementation’s benefits contribute to the increasing orthobiologics demand.

Breakup by Type:

• Knee
• Ankle
• Hip
• Wrist and Shoulder
• Spine
• Others

Knee holds the largest share of the industry

A detailed breakup and analysis of the market based on the type have also been provided in the report. This includes knee, ankle, hip, wrist and shoulder, spine, and others. According to the report, knee accounted for the largest market share.

The high incidence of degenerative conditions in knees like osteoarthritis and injuries such as ligament tears and cartilage damage is acting as another crucial factor driving the demand for orthobiologics. The knee joint, being a weight-bearing joint, is particularly susceptible to wear and tear over time, leading to significant pain and reduced mobility. Orthobiologic treatments, including viscosupplementation and regenerative therapies, are frequently used to alleviate symptoms and improve function in knee conditions. The high prevalence of knee disorders among both the aging population and athletes, combined with the effectiveness of orthobiologic interventions in reducing pain and promoting healing, is bolstering the market demand.

Breakup by Application:

• Osteoarthritis and Degenerative Arthritis
• Spinal Fusion
• Fracture Recovery
• Soft Tissue Injuries
• Maxillofacial and Dental Applications

Osteoarthritis and degenerative arthritis represent the leading market segment 

The report has provided a detailed breakup and analysis of the market based on the application. This includes osteoarthritis and degenerative arthritis, spinal fusion, fracture recovery, soft tissue injuries, and maxillofacial and dental applications. According to the report, osteoarthritis and degenerative arthritis represented the largest segment.

As per the orthobiologics market overview, osteoarthritis and degenerative arthritis are the leading market segments due to their widespread prevalence and impact. These conditions are characterized by the progressive breakdown of joint cartilage, leading to pain, stiffness, and impaired function, particularly in weight-bearing joints like the knees and hips. As the global population ages and more individuals experience these age-related joint issues, the demand for effective treatments grows. Orthobiologic solutions, such as viscosupplementation and regenerative therapies, offer non-surgical options to manage symptoms, improve mobility, and enhance quality of life. Their ability to address the root causes of joint degeneration, combined with a growing preference for MISs is bolstering the orthobiologics market revenue.

Breakup by End User:

• Hospitals and Ambulatory Centers
• Research and Academic Institutes
• Dental Clinics and Facilities
• Orthopedic Clinics

Hospitals and ambulatory centers exhibit a clear dominance in the market 

A detailed breakup and analysis of the market based on the end user have also been provided in the report. This includes hospitals and ambulatory centers, research and academic institutes, dental clinics and facilities, and orthopedic clinics. According to the report, hospitals and ambulatory centers accounted for the largest market share.

Hospitals and ambulatory centers are the biggest end user segment due to their comprehensive diagnostic and treatment capabilities. These facilities are equipped with advanced imaging and surgical technologies that enable precise administration of orthobiologic treatments, such as injections and regenerative therapies. Hospitals and ambulatory centers often offer a range of specialized services, including orthopedic surgery and rehabilitation, which integrate seamlessly with ortho-biologic interventions. Furthermore, the ability to manage complex cases and provide immediate medical support enhances the appeal of these settings for both patients and providers. The concentration of skilled healthcare professionals and access to cutting-edge treatments in these facilities are further contributing to the demand for orthobiologics in these settings.

Breakup by Region:

• North America
  • United States
  • Canada
• Asia-Pacific
  • China
  • Japan
  • India
  • South Korea
  • Australia
  • Indonesia
  • Others
• Europe
  • Germany
  • France
  • United Kingdom
  • Italy
  • Spain
  • Russia
  • Others
• Latin America
  • Brazil
  • Mexico
  • Others
• Middle East and Africa

North America leads the market, accounting for the largest orthobiologics market share

The report has also provided a comprehensive analysis of all the major regional markets, which include North America (the United States and Canada); Asia Pacific (China, Japan, India, South Korea, Australia, Indonesia, and others); Europe (Germany, France, the United Kingdom, Italy, Spain, Russia, and others); Latin America (Brazil, Mexico, and others); and the Middle East and Africa. According to the report, North America represents the largest regional market for orthobiologics.

The orthobiologics market forecast shows that North America leads the market with its high prevalence of musculoskeletal disorders, such as osteoarthritis, expanding geriatric population, and widespread trends of engaging in high levels of physical activity and sports. Advanced healthcare infrastructure and a high standard of medical care in the U.S. and Canada support the adoption of innovative orthobiologic treatments. Moreover, North America is home to major pharmaceutical and biotech companies that invest heavily in R&D, driving the availability of cutting-edge products. The region’s strong regulatory framework and significant healthcare spending further facilitate market growth, making it a leader in the adoption and utilization of orthobiologics.

Competitive Landscape:

• The market research report has also provided a comprehensive analysis of the competitive landscape in the market. Detailed profiles of all major companies have also been provided. Some of the major market players in the orthobiologics industry include Arthrex Inc, Globus Medical Inc., Integra LifeSciences, Johnson & Johnson, Medline Industries Inc., Medtronic plc, NuVasive Inc, Orthofix Medical Inc., Smith & Nephew plc, Stryker Corporation, Terumo Corporation, Wright Medical Group N.V., Zimmer Biomet, etc.
  
  (Please note that this is only a partial list of the key players, and the complete list is provided in the report.)
   
• The competitive landscape is marked by a dynamic interplay between major pharmaceutical companies, specialized biotech firms, and emerging players. Leading companies with a broad portfolio of products and extensive distribution networks are investing heavily in R&D to innovate and enhance their offerings, particularly in areas like viscosupplementation and regenerative therapies. At the same time, smaller biotech firms are driving competition through specialized, cutting-edge solutions and novel technologies, such as stem cell therapies and advanced growth factors. Additionally, the market is characterized by strategic alliances and mergers among orthobiologics companies, which enhance market reach and capabilities. Besides this, regulatory approvals and clinical advancements significantly influence market dynamics, making the industry highly competitive and continuously evolving.

Orthobiologics Market News:

• June 2025: Bone Biologics Corporation's recent public offering of $5.0 million, along with $10.0 million in possible warrant exercises, signifies a crucial milestone for the orthobiologics pioneer. Focusing on the Nell-1 protein, a groundbreaking bone regeneration technology, the company seeks to take advantage of a $5.89 billion market expanding at 5.1% each year. Here’s why investors need to closely observe its capital allocation strategy and growth path.
• May 2025: Xtant Medical Holdings, Inc., an international medical technology firm dedicated to surgical solutions for spinal, orthopedic, and wound care challenges, launched OsteoFactor Pro™, a naturally sourced combination of allogeneic growth factors designed to enhance bone healing and aid surgical outcomes in orthopedic and spine operations. OsteoFactor Pro™ is a naturally sourced formulation abundant in growth factors that boosts the biological activity and regenerative capacity of any orthobiologic scaffold.
• March 2025: Modern Sports Medicine & Wellness (MSMW), a frontrunner in innovative non-surgical orthobiologic therapies and telehealth services, has revealed a strategic collaboration with NeuralCure AI, an innovative AI-driven decision support platform that improves medical diagnostics and precise treatment planning. This partnership will incorporate NeuralCure AI's predictive analytics, diagnostic improvements, and treatment simulations into MSMW's operations, offering doctors enhanced data-driven insights to improve patient care.
• March 2025: MTF Biologics, a worldwide nonprofit committed to saving and healing lives through the advancement of tissue and organ donation, transplantation, and research, has broadened its strategic partnership with Kolosis BIO (Kolosis), a top provider of orthobiologics solutions. Through this partnership, Kolosis has expanded the range of allograft solutions from MTF Biologics that it represents and distributes to now feature DBX® Mix and DBX® Putty, offering surgeons and their patients a diverse array of demineralized cortical bone matrix (DBM) options.
• February 2025: Contura Orthopedics has recently revealed the establishment of Contura Orthopedics (Canada) Ltd., representing a significant advancement in the company’s worldwide growth. This comes after Health Canada authorized Arthrosamid® in 2024, making this innovative hydrogel injection accessible to patients suffering from knee pain due to osteoarthritis (OA) in North America.
• May 2024: AKVA Surgical partnered with BONESUPPORT™ to introduce the CERAMENT® portfolio in Australia. BONESUPPORT, known for its innovative injectable bioceramic bone graft substitutes, offers products like CERAMENT® BONE VOID FILLER and CERAMENT® G, which use the proprietary CERAMENT® technology to promote bone remodeling and drug elution. These solutions provide clinical benefits in treating trauma, chronic osteomyelitis, diabetic foot osteomyelitis, and revision arthroplasty.

Orthobiologics Market Report Scope:

Key Questions Answered in This Report:

• How has the global orthobiologics market performed so far, and how will it perform in the coming years?
• What are the drivers, restraints, and opportunities in the global orthobiologics market?
• What is the impact of each driver, restraint, and opportunity on the global orthobiologics market?
• What are the key regional markets?
• Which countries represent the most attractive orthobiologics market?
• What is the breakup of the market based on the product?
• Which is the most attractive product in the orthobiologics market?
• What is the breakup of the market based on the type?
• Which is the most attractive type in the orthobiologics market?
• What is the breakup of the market based on the application?
• Which is the most attractive application in the orthobiologics market?
• What is the breakup of the market based on the end user?
• Which is the most attractive end user in the orthobiologics market?
• What is the competitive structure of the market?
• Who are the key players/companies in the global orthobiologics market?

Key Benefits for Stakeholders:

• IMARC’s industry report offers a comprehensive quantitative analysis of various market segments, historical and current market trends, market forecasts, and dynamics of the orthobiologics market from 2019-2033.
• The research report provides the latest information on the market drivers, challenges, and opportunities in the global orthobiologics market.
• The study maps the leading, as well as the fastest-growing, regional markets. It further enables stakeholders to identify the key country-level markets within each region.
• Porter's five forces analysis assists stakeholders in assessing the impact of new entrants, competitive rivalry, supplier power, buyer power, and the threat of substitution. It helps stakeholders to analyze the level of competition within the orthobiologics industry and its attractiveness.
• The competitive landscape allows stakeholders to understand their competitive environment and provides insight into the current positions of key players in the market.