Bone Graft And Substitutes Market Report

Market Overview:

The global bone graft and substitutes market size reached US$ 3.0 Billion in 2022. Looking forward, IMARC Group expects the market to reach US$ 4.2 Billion by 2028, exhibiting a growth rate (CAGR) of 6% during 2023-2028. The rising prevalence of orthopedic problems and periodontal diseases, continual technological advancements in bone grafting procedures, and the growing demand for dental implants among the masses represent some of the key factors driving the market.

The Rising Prevalence of Orthopedic Problems and Periodontal Diseases Augmenting the Market Growth

The bone graft and substitutes market has been experiencing continuous growth. The growing prevalence of bone and joint disorders, such as osteoporosis, arthritis, and bone fractures, is becoming a major health concern globally. The rising number of geriatric population that is particularly vulnerable to these conditions due to the gradual loss of bone mass and weakened joint strength has created a need for bone graft and substitutes. As a sustainable solution for patients suffering from these conditions, these substitutes are facing high market demand. Moreover, an increase in sports-related injuries and accidents causing numerous bone and joint disorders has further augmented the demand for bone graft and substitutes, particularly for the younger population.

Competitive analysis such as market structure, market share by key players, player positioning, top winning strategies, competitive dashboard, and company evaluation quadrant has been covered in the report. Also, detailed profiles of all major companies have been provided. The market structure is fragmented with several small and large vendors operating in the industry. The volume of new entrants is moderate in the bone graft and substitutes industry due to the strong presence of the leading players, intense competition and high initial investments. However, considerable expansion of the market is attracting several cross-industry vendors.

What are Bone Graft and Substitutes?

Bone graft and substitutes are synthetic, inorganic, or biologically organic combinations that serve to replace missing bones or repair bone fractures. They are commercially available in pellets, moldable putty, injectables, and solid block forms. They contain an osteoconductive matrix that acts as a filler to promote wound healing, osteoinductive proteins that support the mitogenesis of identical bone cells, and osteogenic cells that form the bone in the appropriate environment. Along with these components, bone grafts and substitutes may also contain demineralized bone matrix, platelet-rich plasma, tricalcium phosphate ceramics, and other polymer-based substitutes. These materials are thermally nonconductive, bioresorbable, and do not cause any antigen-antibody reaction or adverse inflammatory response. As a result, they promote wound healing, support the mitogenesis of identical bone cells, and aid in new bone formation. Because of these attributes, bone grafts and substitutes are widely used in spinal, facial, foot, ankle, or trauma surgeries to aid in the healing of fractures and bone injuries.

COVID-19 Impact:

The bone graft and substitutes market has been heavily impacted by the COVID-19 pandemic. With routine checkups being avoided, there was a decrease in checkups and related surgeries, resulting in a downturn in the market in the second and third quarters of 2020. Moreover, human resource availability issues in manufacturing bone grafts and substitutes were faced due to the pandemic, leading to supply chain disruptions. The pandemic led to transportation modes being abandoned, obstructing the availability of feedstocks needed to manufacture bone grafts. Healthcare systems have been focused on addressing the pandemic, leading to disruptions in supply chains and a shortage of these products in some regions. Nonetheless, the demand for bone grafts and substitutes has increased due to a surge in the treatment of fractures and injuries resulting from accidents or falls. However, the market is expected to recover as governments around the world began relaxing restrictions and resuming business activities.

Bone Graft and Substitutes Market Trends:

The global bone graft and substitutes market is witnessing significant growth due to the growing geriatric population that is susceptible to several bone and joint disorders, such as osteoporosis, arthritis, and bone fractures. In line with this, the rising number of orthopedic surgeries on the global level, along with the growing preference for minimally invasive procedures, is resulting in a higher product uptake. Continual technological advancements in surgical technologies, such as such as rapid prototyping and 3D printing for the fabrication of free-form biomaterial scaffolds, is also fueling the demand for bone graft and substitutes. Also, the advent of new polymer and ceramic products with biologically superior characteristics for enhanced tissue regeneration is creating lucrative growth opportunities in the market. Additionally, considerable rise in sports injuries and road accidents is contributing to the growth of the market. Furthermore, extensive research and development (R&D) activities focusing on the enhancement of bioactivity of bone graft substitutes is further creating a positive market outlook. Some of the other factors contributing to the market include the rising awareness regarding the benefits of bone regeneration through biologics, widespread availability of bone grafting products in different shapes and sizes, rising health expenditure and inflating disposable income levels.

Key Market Segmentation:

IMARC Group provides an analysis of the key trends in each sub-segment of the global bone graft and substitutes market report, along with forecasts at the global and regional level from 2023-2028. Our report has categorized the market based on material type, application and end user.

Material Type Insights:

• Allografts 
  • Machined Allografts
  • Demineralized Bone Matrix (DBMs)
• Bone Graft Substitutes
  • Bone Morphogenic Proteins (BMPs)
  • Synthetic Bone Grafts
• Cell-based Matrices
• Others
   

The report has provided a detailed breakup and analysis of the bone graft and substitutes market based on the material type. This includes allografts (machined allografts and demineralized bone matrix [DBMs]), bone graft substitutes (bone morphogenic proteins [BMPs] and synthetic bone grafts), cell-based matrices, and others. According to the report, allografts represented the largest segment due to the growing prevalence of bone and joint disorders and the rising incidence of road accidents and sports injuries. In addition, the demand for hot bone graft and substitutes has been largely influenced by the lesser risk of donor site morbidity and shorter operating time, making them an attractive option for surgeons.

Application Insights:

• Spinal Fusion
• Trauma
• Joint Reconstruction
• Foot and Ankle
• Dental Bone Grafting
• Craniomaxillofacial
• Others
   

A detailed breakup and analysis of the bone graft and substitutes market based on the application has also been provided in the report. This includes spinal fusion, trauma, joint reconstruction, foot and ankle, dental bone grafting, craniomaxillofacial, and others. According to the report, spinal fusion accounted for the largest market share due to the increasing prevalence of spinal disorders, such as degenerative disc disease, spinal stenosis, and spondylolisthesis, which require spinal fusion surgeries. Moreover, the paradigm shift toward minimally invasive procedures coupled with the growing awareness among patients about the benefits of spinal fusion is further fueling the segment growth.  

End User Insights:

• Hospitals
• Surgical Centres
• Clinics
• Others
   

A detailed breakup and analysis of the bone graft and substitutes market based on the end user has also been provided in the report. This includes hospitals, surgical centres, clinics, and others. According to the report, hospitals accounted for the largest market share on account of the increasing number of increasing number of orthopedic surgeries across the globe. In addition, the growing demand for synthetic bone graft substitutes along with along bone regeneration in a hospital setting is augmenting the end user segment.

Regional Insights:

• North America
• Europe
• Asia Pacific
• Middle East and Africa
• Latin America
   

The report has also provided a comprehensive analysis of all the major regional markets, which include North America, Europe, Asia Pacific, Latin America, and the Middle East and Africa. According to the report, North America was the largest market for bone graft and substitutes. Some of the factors driving the North America bone graft and substitutes market included the rising health consciousness among the masses, presence of several key players, rising medical expenditure, rising prevalence of bone and joint disorders, and the growing geriatric population.

Competitive Landscape:

The report has also provided a comprehensive analysis of the competitive landscape in the global bone graft and substitutes market. Some of the companies covered in the report include:

• Zimmer Biomet Dental
• DePuy Synthes
• Wright Medical Technology
• Medtronic Plc.
• Stryker Corporation
• NuVasive Inc.
• Arthrex Inc.
• Integra LifeSciences
• Baxter International Inc.
• Musculoskeletal Transplant Foundation
• Bacterin International Holdings
• SeaSpine
• LifeNet Health
   

Please note that this only represents a partial list of companies, and the complete list has been provided in the report.

Report Coverage:

Key Questions Answered in This Report:

• How has the global bone graft and substitutes market performed so far, and how will it perform in the coming years?
• What are the drivers, restraints, and opportunities in the global bone graft and substitutes market?
• What is the impact of each driver, restraint, and opportunity on the global bone graft and substitutes market?
• What are the key regional markets?
• Which countries represent the most attractive bone graft and substitutes market?
• What is the breakup of the market based on the material type?
• Which is the most attractive material type in the bone graft and substitutes market?
• What is the breakup of the market based on the application?
• Which is the most attractive application in the bone graft and substitutes market?
• What is the breakup of the market based on the end user?
• Which is the most attractive end user in the bone graft and substitutes market?
• What is the competitive structure of the global bone graft and substitutes market?
• Who are the key players/companies in the global bone graft and substitutes market?

Key Benefits for Stakeholders:

• IMARC’s report offers a comprehensive quantitative analysis of various market segments, historical and current market trends, market forecasts, and dynamics of the bone graft and substitutes market from 2017-2028.
• The research study provides the latest information on the market drivers, challenges, and opportunities in the global bone graft and substitutes market.
• The study maps the leading, as well as the fastest-growing, regional markets. It further enables stakeholders to identify the key country-level markets within each region.
• Porter's five forces analysis assist stakeholders in assessing the impact of new entrants, competitive rivalry, supplier power, buyer power, and the threat of substitution. It helps stakeholders to analyze the level of competition within the bone graft and substitutes industry and its attractiveness.
• Competitive landscape allows stakeholders to understand their competitive environment and provides an insight into the current positions of key players in the market.