The global pulmonary arterial hypertension (PAH) drugs market size reached US$ 7.3 Billion in 2022 Looking forward, IMARC Group expects the market to reach US$ 9.9 Billion by 2028, exhibiting a growth rate (CAGR) of 5.2% during 2023-2028.
Pulmonary arterial hypertension (PAH) refers to a life-threatening medical condition characterized by high blood pressure in the arteries that connect the heart to the lungs. It causes the artery walls to tighten and narrow down, thereby exerting additional pressure on the heart to pump blood and weakening the muscles. In adverse cases, it can also compromise the heart’s capacity to pump blood, thus eventually causing heart failure. PAH is characterized by shortness of breath, fatigue and swelling in ankles and legs. It is diagnosed through various tests, such as an echocardiogram, computer tomography (CT) scans, chest X-rays and ventilation-perfusion scans. It is usually treated using various drugs, such as endothelin receptor antagonists (ERAs), vasodilators, calcium channel blockers (CCBs), anticoagulants, diuretics and cardiac glycosides. These drugs can be inhaled, injected or orally administered.
The increasing prevalence of cardiovascular and pulmonary disorders is one of the key factors driving the growth of the market. Furthermore, the rising geriatric population that is more susceptible to such medical ailments is providing a boost to the market growth. In line with this, changes in lifestyles, such as excessive alcohol consumption, a lack of physical activity, and unhealthy dietary patterns, have enhanced the risks of hypertension and high blood pressure. This, along with the development of novel orphan drugs and technologically advanced devices for the treatment of PAH, is favoring the market growth. Other factors, including increasing awareness among the masses regarding the available treatment alternatives for PAH, and improving healthcare infrastructure across the globe, are expected to drive the market further.
Key Market Segmentation:
IMARC Group provides an analysis of the key trends in each sub-segment of the global pulmonary arterial hypertension (PAH) drugs market report, along with forecasts at the global, regional and country level from 2023-2028. Our report has categorized the market based on drug class, route of administration and end user.
Breakup by Drug Class:
Endothelin Receptor Antagonists (ERAs)
Phosphodiesterase-5 (PDE-5) Inhibitors
Soluble Guanylate Cyclase (sGC) Stimulators
Calcium Channel Blockers (CCBs)
Prostacyclin and Prostacyclin Analogs
Breakup by Route of Administration:
Breakup by End User:
Breakup by Region:
Middle East and Africa
The report has also analysed the competitive landscape of the market with some of the key players being Actelion Pharmaceuticals Ltd (Johnson & Johnson), Arena Pharmaceuticals Inc., AstraZeneca PLC, Bayer Aktiengesellschaft, Daiichi Sankyo Company Limited, Gilead Science Inc., GlaxoSmithKline PLC, Merck KGaA, Novartis International AG, Pfizer Inc. and United Therapeutics Corporation.
Base Year of the Analysis
Drug Class, Route of Administration, End User, Region
Asia Pacific, Europe, North America, Latin America, Middle East and Africa
United States, Canada, Germany, France, United Kingdom, Italy, Spain, Russia, China, Japan, India, South Korea, Australia, Indonesia, Brazil, Mexico
Actelion Pharmaceuticals Ltd (Johnson & Johnson), Arena Pharmaceuticals Inc., AstraZeneca PLC, Bayer Aktiengesellschaft, Daiichi Sankyo Company Limited, Gilead Science Inc., GlaxoSmithKline PLC, Merck KGaA, Novartis International AG, Pfizer Inc. and United Therapeutics Corporation
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Key Questions Answered in This Report
The global Pulmonary Arterial Hypertension (PAH) drugs market was valued at US$ 7.3 Billion in 2022.
We expect the global Pulmonary Arterial Hypertension (PAH) drugs market to exhibit a CAGR of 5.2% during 2023-2028.
The rising prevalence of cardiovascular and pulmonary disorders among individuals, owing to excessive alcohol consumption, lack of physical activity, unhealthy dietary patterns, etc., is primarily driving the global Pulmonary Arterial Hypertension (PAH) drugs market.
The sudden outbreak of the COVID-19 pandemic had led to the growing number of R&D activities pertaining to specialty generic drugs for combating the spread of the coronavirus infection, thereby negatively impacting the global market for Pulmonary Arterial Hypertension (PAH) drugs.
Based on the drug class, the global Pulmonary Arterial Hypertension (PAH) drugs market has been segregated into Endothelin Receptor Antagonists (ERAs), vasodilators, Phosphodiesterase-5 (PDE-5) inhibitors, Soluble Guanylate Cyclase (sGC) stimulators, Calcium Channel Blockers (CCBs), prostacyclin and prostacyclin analogs, and others. Among these, prostacyclin and prostacyclin analogs currently exhibit a clear dominance in the market.
Based on the route of administration, the global Pulmonary Arterial Hypertension (PAH) drugs market can be bifurcated into inhalation, injectable, and oral administration. Currently, oral administration holds the largest market share.
On a regional level, the market has been classified into North America, Asia Pacific, Europe, Latin America, and Middle East and Africa, where North America currently dominates the global market.
Some of the major players in the global Pulmonary Arterial Hypertension (PAH) drugs market include Actelion Pharmaceuticals Ltd (Johnson & Johnson), Arena Pharmaceuticals Inc., AstraZeneca PLC, Bayer Aktiengesellschaft, Daiichi Sankyo Company Limited, Gilead Science Inc., GlaxoSmithKline PLC, Merck KGaA, Novartis International AG, Pfizer Inc., and United Therapeutics Corporation.
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