Nucleotides Market

Global Nucleotides Market:

The global nucleotides market size reached USD 762.7 Million in 2024. Looking forward, IMARC Group expects the market to reach USD 1,288.3 Million by 2033, exhibiting a growth rate (CAGR) of 6% during 2025-2033. North America represents the leading region driven by advancements in biotechnology and newborn nutrition. Moreover, the rising demand for infant nutrition and the increasing use of animal feed are supporting the market. Additionally, the heightened demand for functional food and beverages is strengthening the market growth.

Nucleotides Market Analysis:

• Major Market Drivers: The expansion of functional foods and beverages is propelling the market.
• Key Market Trends: The growing use of nucleotide supplements in dairy products is acting as a significant growth-inducing factor.
• Competitive Landscape: Some of the major market companies include CJ CheilJedang Corporation, Exotic Biosolutions, F. Hoffmann-La Roche AG, Jena Bioscience GmbH, Koninklijke DSM N.V., Lallemand Inc., Meridian Bioscience Inc., Nanjing Biotogether Co. Ltd., Ohly GmbH (Associated British Foods plc), Promega Corporation, Starlake Bioscience Co. Inc., and Thermo Fisher Scientific Inc., among many others.
• Geographical Trends: The market in North America is driven by advancements in biotechnology and newborn nutrition. Asia-Pacific is witnessing significant demand due to growth in the pharmaceutical and animal feed businesses. Europe emphasizes functional meals and infant formulas, while Latin America benefits from increasing nucleotide use in animal feed. Furthermore, the Middle East and Africa area is undergoing moderate market expansion, primarily in healthcare and nutrition.
• Challenges and Opportunities: The high production cost is hampering the market. However, improving manufacturing procedures and boosting productivity to achieve cost-effectiveness will continue to catalyze the market over the forecast period.

Nucleotides Market Trends:

Growing Market for Nucleotide Therapeutics

The market for nucleotide-based therapies is growing as researchers are learning more about the ability to treat genetic diseases, cancers, and viral diseases with nucleotides. Companies are working on mRNA vaccines, RNA therapies, and gene editing tools involving nucleotides. Since biopharmaceutical businesses are concentrating on these new therapies, investments in the market for nucleotides are growing. Progress in the technology for Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), which is based on the nucleotide sequence, is also supporting the market growth. This force is urging pharmaceutical businesses to develop nucleotide-based therapies, which will enhance the outcomes for the patient through personalized medicine. The market is always growing as the world's healthcare industry places greater importance on the requirement for more focused and effective medicine, especially in the area of oncology and rare genetic conditions, with the result that the demand for nucleotide-based therapies grows. In 2024, N4 Pharma, a pharmaceutical specialist focused on creating Nuvec®, an innovative delivery mechanism intended for transporting nucleotides for cancer therapies and vaccines, established a research collaboration with SRI to integrate Nuvec with SRI’s exclusive FOX Three Molecular Guidance System™ (MGS), aiming to jointly market the integrated technology.

Increasing Biotech Research and Development Activities

Researche and development (R&D) activities in the biotech sector are driving the market for nucleotides. Scientists are always researching on the nucleotides due to their function in DNA and RNA synthesis, gene expression, and the mechanisms of diseases. Increased investments in biotechnology fields are aiding this explosion in R&D, thus emerging with highly advanced nucleotide-based products. Academic institutions and laboratories are conducting the development of novel nucleotide analogs and better synthesis techniques. This science is key in the identification of novel drug candidates and the growth in the application of nucleotides in diagnostics, vaccines, and therapies. With governments and private institutions targeting the advancement in biotech, the need for high-quality nucleotide reagents and tools is steadily increasing, thereby driving the market across the world. In 2024, The Government of India approved BioE3 (Biotechnology for Economy, Environment, and Employment) Policy, which aimed to enhance innovation-oriented research and entrepreneurship in high-efficiency biomanufacturing.

Innovative Developments in Precision Medicine

Rise in precision medicine is driving the market for nucleotides. With increasingly individualized medicine becoming tailored to the individual's genetic profile, there is growing demand for nucleotide-based diagnostics and therapies. Genetic testing using nucleotides is identifying the particular genetic mutation in an individual and offering insights into the patient's predisposition to diseases. This helps create better tailored therapies. Scientists are increasingly investigating how therapies involving nucleotides need to be increasingly individualized in order to enhance the safety and efficacy of the therapies. With the improvement in precision medicine, the need for nucleotides in the form of primers, probes, and enzyme molecules is on the rise, thus propelling the market growth. IMARC Group predicts that the global precision medicine market is projected to attain USD 179.4 Billion by 2033.

Nucleotides Market Growth Drivers:

Growing Use of DNA and RNA Synthesis

Utilization of DNA and RNA synthesis technology is driving the market for nucleotides. Nucleotides are the precursors for DNA and RNA, and the use in the field of gene synthesis, cloning, and sequencing is growing. With the growing advancement in the field of genetics, researchers are increasingly using nucleotide synthesis in the construction of personalized DNA and RNA strands for the purpose of evaluating the function of the gene and the regulation of the expression of the gene. Expanded use of synthetic biology for agricultural, pharmaceutical, and environmental science purposes is also driving the demand. Firms are innovating in the supply of quality, high-end nucleotide synthesis equipment, and this is expanding market prospects. With the growth in synthetic biology, the demand for nucleotides for the construction of the sequence in the genes is increasingly growing, driving the market.

Increased Emphasis on Researching Infectious Diseases

The increasing need for infectious diseases research, particularly after the pandemic in the world, is primarily responsible for the market for nucleotides. Scientists are increasingly using nucleotides for diagnostic device development, vaccines, and antiviral drug development. Nucleotides-based products, for example, oligonucleotides, are used for the construction of molecular diagnostics and pathogen identification kits. With the increasing need for quick, qualitative, and scalable solutions for emerging infectious disease management, the application of nucleotide-based products is advancing at a fast pace. Continued interest in the identification of new treatments for infectious diseases ensures that the market for nucleotides continues to be one of the most vital participants in the world's disease management activities.

Technology Developments for Nucleotide Synthesis and Purification

The market for nucleotides has been driven by the progress in technology for the synthesis and purification of nucleotides. Innovations in the field of automation, high-throughput sequencing, and extraction methods for nucleic acids are facilitating the most economical and efficient production of nucleotides. Emerging methods for the purification of nucleotides are also increasing the quality of the final outputs, which is vital for application in research, diagnostics, and drug development. There is constant innovation by players in this market, which is facilitating the creation of increasingly scalable and accurate techniques for purifying and synthesizing nucleotides. Such advancements are allowing researchers and biopharmaceutical businesses to access the nucleotides for the purpose of working with the nucleotides, driving their application across many ends such as drug discovery through personalized medicine.

Global Nucleotides Industry Segmentation:

IMARC Group provides an analysis of the key trends in each segment of the market, along with the nucleotides market forecasts at the global, regional, and country levels for 2025-2033. Our report has categorized the market based on type, technology, form, and application.

Breakup by Type:

• Food Grade
• Lab Grade
• Industry Grade
• Others
   

The report has provided a detailed breakup and analysis of the market based on the type. This includes food grade, lab grade, industry grade, and others.

Food grade nucleotides are commonly employed in infant formulae and functional meals, while lab grade nucleotides are required for scientific and medicinal uses. Furthermore, industry grade nucleotides are utilized in animal feed to increase livestock welfare and development, particularly in aquaculture and poultry production.

Breakup by Technology:

• TaqMan Allelic Discrimination
• Gene Chips and Microarrays
• SNP by Pyrosequencing
• Others
   

The report has provided a detailed breakup and analysis of the market based on the technology. This includes TaqMan allelic discrimination, gene chips and microarrays, SNP by pyrosequencing, and others.

TaqMan allelic discrimination improves SNP detection accuracy. Gene chips and microarrays enable high-throughput genotyping and comprehensive genetic analysis. Additionally, SNP by pyrosequencing provides precise sequencing capabilities, which accelerates research and diagnosis. Together, these innovations are helping to drive the nucleotides market statistics.

Breakup by Form:

• Liquid
• Powder
   

The report has provided a detailed breakup and analysis of the market based on the form. This includes liquid and powder.

Liquid nucleotides are easy to handle and dissolve quickly, making them appropriate for research and therapeutic settings. In contrast, powder nucleotides have a longer shelf life and can be used in a variety of formulations. This dual offering improves market accessibility while also advancing biotechnology and molecular biology, thereby inflating the nucleotides market revenue.

Breakup by Application:

• Pharmaceutical
• Food and Animal Feed Additives
• Drug Discovery
• Others
   

The report has provided a detailed breakup and analysis of the market based on the application. This includes pharmaceutical, food and animal feed additives, drug discovery, and others.

The market is driven by the increasing pharmaceuticals industry, where nucleotides play an important role in drug formulation and development. In food and animal feed additives, nucleotides are important additions for improving nutritional content and digestive health in animal feed. Furthermore, their importance in drug discovery hastens the identification of therapeutic targets, pushing advances in biotechnology and healthcare. These segments are bolstering the nucleotides market demand.

Breakup by Region:

• North America
  • United States
  • Canada
• Asia-Pacific
  • China
  • Japan
  • India
  • South Korea
  • Australia
  • Indonesia
  • Others
• Europe
  • Germany
  • France
  • United Kingdom
  • Italy
  • Spain
  • Russia
  • Others
• Latin America
  • Brazil
  • Mexico
  • Others
• Middle East and Africa
   

The nucleotides market research report has also provided a comprehensive analysis of all the major regional markets, which include North America (the United States and Canada); Asia-Pacific (China, Japan, India, South Korea, Australia, Indonesia, and others); Europe (Germany, France, the United Kingdom, Italy, Spain, Russia, and others); Latin America (Brazil, Mexico, and others); and the Middle East and Africa.

The nucleotide market in North America benefits from strong research centers and considerable pharmaceutical investments. Asia-Pacific is rising rapidly due to increased demand in biotechnology and the healthcare sector. Europe benefits from strong regulatory support and a thriving pharmaceutical industry, which drives nucleotide innovation. Latin America is poised for expansion, backed by increased health awareness and agricultural uses. The Middle East and Africa are steadily evolving, with a growing interest in biotechnology and nutritional upgrades for food and feed.

Competitive Landscape:

As per the nucleotides market overview, the market research report has provided a comprehensive analysis of the competitive landscape. Detailed profiles of all major market companies have also been provided. Some of the key players in the market include:

• CJ CheilJedang Corporation
• Exotic Biosolutions
• F. Hoffmann-La Roche AG
• Jena Bioscience GmbH
• Koninklijke DSM N.V.
• Lallemand Inc.
• Meridian Bioscience Inc.
• Nanjing Biotogether Co. Ltd.
• Ohly GmbH (Associated British Foods plc)
• Promega Corporation
• Starlake Bioscience Co. Inc.
• Thermo Fisher Scientific Inc.
   

(Please note that this is only a partial list of the key players, and the complete list is provided in the report.)

Nucleotides Market Recent Developments:

• August 2025: Cohance Lifesciences, a global organization for contract research, development, and manufacturing, announced an investment of $10 million to enhance cGMP bioconjugation capabilities at its U.S. subsidiary NJ Bio. This investment in the U.S. aims to bolster its worldwide expansion in specialized technology-driven fields, improving support for innovators from early development to late-phase clinical supply. The establishment of a cGMP compliant bioconjugation suite at NJ Bio’s Princeton, New Jersey location enhances the company's ability to provide fully integrated antibody-drug conjugate (ADC) solutions, according to Cohance.
• July 2025: BioSpring revealed plans for a pharmaceutical plant focused on nucleic acid therapies in Offenbach. This growth signifies an important achievement for the company and Germany's swiftly advancing biotech industry. The new facility at the Offenbach Innovation Campus will concentrate on the large-scale manufacture of synthetic DNA and RNA segments—referred to as oligonucleotides—employed in cutting-edge treatments for cancer, genetic, and metabolic disorders.
• May 2025: Oligo Factory revealed its expansion of offerings to incorporate a low-scale oligo synthesis capability during the TIDES USA: Oligonucleotide and Peptide Therapeutics conference, scheduled for May 19-22 in San Diego.
• February 2025: TriLink BioTechnologies, a Maravai® LifeSciences company and a global supplier of life science reagents and services, has collaborated with Avantor, Inc., a prominent global supplier of essential products and services to clients in the life sciences and advanced technology sectors, to enhance the accessibility of its cutting-edge nucleic acid products to clients throughout Europe, the Middle East, and Africa (EMEA). This collaboration is anticipated to enhance the ordering procedure and provide reduced lead times for European clients, expanding availability to TriLink’s innovative nucleic acid technologies.
• September 2024: NASA’s GeneLab project received an Illumina NovaSeq 6000 sequencing instrument. This state-of-the-art sequencer can generate 3 trillion bases of sequencing data every two days.
• August 2024: The Medical Research Council (MRC), in collaboration with the Biotechnology and Biological Sciences Research Council (BBSRC), awarded £7 Million to help establish the MRC-AstraZeneca-University of Cambridge joint Functional Genomics Screening Laboratory (FGSL) at the Milner Therapeutics Institute (MTI) in Cambridge.
• May 2024: N4 Pharma announced a collaboration with SRI to target and treat cells in the human body that have been previously unreachable.

Nucleotides Market Report Scope:

Key Questions Answered in This Report

• How has the global nucleotides market performed so far, and how will it perform in the coming years?
• What has been the impact of COVID-19 on the global nucleotides market?
• What are the key regional markets?
• What is the breakup of the market based on the type?
• What is the breakup of the market based on the technology?
• What is the breakup of the market based on the form?
• What is the breakup of the market based on the application?
• What are the various stages in the value chain of the industry?
• What are the key driving factors and challenges in the industry?
• What is the structure of the global nucleotides market, and who are the key players?
• What is the degree of competition in the industry?

Key Benefits for Stakeholders:

• IMARC's industry report offers a comprehensive quantitative analysis of various market segments, historical and current market trends, market forecasts, and dynamics of the nucleotides market from 2019-2033.
• The research report provides the latest information on the market drivers, challenges, and opportunities in the global nucleotides market.
• The study maps the leading, as well as the fastest-growing, regional markets. It further enables stakeholders to identify the key country-level markets within each region.
• Porter's five forces analysis assists stakeholders in assessing the impact of new entrants, competitive rivalry, supplier power, buyer power, and the threat of substitution. It helps stakeholders to analyze the level of competition within the nucleotides industry and its attractiveness.
• The competitive landscape allows stakeholders to understand their competitive environment and provides insight into the current positions of key players in the market.